银河与国际外浩繁互助单元团结宣布的局部文章与择要(包罗 CTCCTEC,肿瘤细胞与分子生物学,脑神经学,内排泄学,免疫学,血液学,病原微生物学,C-反响卵白 CRP,免疫脂质体溶破技能使用等



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    • 68R2. iFISH全主动CTC扫描仪荣获二类医疗东西注册证

      要害词:全主动6-通道 3D 扫描、全波长抗荧光淬灭剂
      互助单元:银河生物
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    • 68R1. 瘤标-iFISH(NC) 全方位检测活性与坏去世瘤标阳性CTC、CTEC

      要害词:区分与原位团结检测坏去世及活性异倍体CTC、CTEC;PD-L1/HER2 等瘤标卵白表达;及时监测疗效与肿瘤耐药;坏去世与活性比对性单细胞测序
      互助单元:银河生物
      ###
    • 67. J. Mi, F. Yang, J, Liu, M. Liu, A.Y. Lin, D.D. Wang, P.P. Lin, Q. Zeng (2022) Case report: Post-therapeutic laryngeal carcinoma patient possessing a high ratio of aneuploid CTECs to CTCs rapidly developed de novo malignancy in pancreas. Front Oncol 12:981907

      要害词:MRD、高比值CTEC/CTC、展望肿瘤产生
      互助单元:广州中山大学五院、中国医学迷信院暨北京协和医学院肿瘤医院、国度癌症中心、国度肿瘤临床医学研讨中心、分子肿瘤学国度重点实行室、银河生物
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    • 67R1. T. Han, J. Zhang, D. Xiao, B. Yang, L. Chen, C. Zhai, F. Ding, Y. Xu, X. Zhao, J. Zhao (2022) Circulating Tumor-Derived Endothelial Cells: An Effective Biomarker for Breast Cancer Screening and Prognosis Prediction. J Oncol 2022: 5247423

      要害词:CD31+ CTEC、乳腺癌筛查、预后
      互助单元:西安交大医学院隶属医院、福建医科大学隶属泉州第一医院、上海张江转化医学中心、上海宝藤医学查验所、银河生物
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    • 66. M. Li, F. Gao, X, Ren, G. Dong, H. Chen, A.Y. Lin, D.D. Wang, M. Liu, P.P. Lin, S. Shen, H. Jiang, C. Yang, X. Zhang, X. Zhao, Q. Zhu, M. Li, Y Cui, S. Lin (2022) Nonhematogenic circulating aneuploid cells confer inferior prognosis and therapeutic resistance in gliomas. Cancer Sci 113:3535–3546

      要害词:胶质瘤、血脑屏蔽毁坏、CD31- CTC 及CD31+ CTEC、医治耐受、预后
      互助单元:中国国度神经体系疾病研讨中心、都城医科大学隶属北京天坛医院神经内科、北京脑肿瘤研讨中心、浙江省人民医院神经内科、美国俄克拉荷马州大学医学中心、银河生物
      ######
    • 65. Z. Li, L. Fan, Y. Wu, Y. Niu, X. Zhang, B. Wang, Y. Yao, C. Chen, N. Qi, D. D. Wang, P. P. Lin, D. Tang, W. Gao (2022) Analysis of the prognostic role and biological characteristics of circulating tumor cell-associated white blood cell clusters in non-small cell lung cancer. J Thorac Dis 14:1544-1555

      要害词: CTC-WBC 细胞团、较差预后、非小细胞肺癌 NSCLC
      互助单元:复旦大学隶属上海华东医院、银河生物
      ######
    • 64. A.Y. Lin, D.D. Wang, L. Li and P.P. Lin (2021) Identification and Comprehensive Co-Detection of Necrotic and Viable Aneuploid Cancer Cells in Peripheral Blood. Cancers 13:5108.

      要害词:检测活性与坏去世异倍体CTC及CTEC、及时评价疗效、检测MRD、SE-iFISH (NC)
      互助单元:银河生物
      ######
    • 63. T. Zhang, L. Zhang, Y. Gao, Y. Wang, Y. Liu, H. Zhang, Q. Wang, F. Hu, J. Li, J. Tan, D.D. Wang, O. Gires, P.P. Lin and B. Li (2021) Role of aneuploid circulating tumor cells and CD31+ circulating tumor endothelial cells in predicting and monitoring anti-angiogenic therapy efficacy in advanced NSCLC. Mol Oncol 15:2891-2909

      要害词:肿瘤复活血管克制剂贝伐单抗、CTC与CTEC、EMT与EndoMT、桑基定向剖析、疗效展望与评价、及时监测耐药、NSCLC
      互助单元:都城医科大学隶属北京胸科医院、德国慕尼黑大学医学中心、银河生物
      ######
    • 63R1. J. Goveia et al. (2020) An Integrated Gene Expression Landscape Profiling Approach to Identify Lung Tumor Endothelial Cell Heterogeneity and Angiogenic Candidates. Cancer Cell 37:21-36.

      要害词:肿瘤血管内皮细胞TEC、单细胞RNA测序、TEC亚类、免疫监督、NSCLC
      互助单元:广东中山大学、华大基因、德国、比利时等多国科研团队
      ######
    • 63R2. S Luo, Y Ou, T Zheng, H Jiang, Y Wu, J Zhao and Z Zhang (2021) Optimal Strategy for Colorectal Cancer Patients’ Diagnosis Based on Circulating Tumor Cells and Circulating Tumor Endothelial Cells by Subtraction Enrichment and Immunostaining-Fluorescence In Situ Hybridization Combining with CEA and CA19-9. J. Oncol 1517488

      要害词:结直肠癌、帮助诊断、SE-iFISH、CTC及CTEC、CEA及CA19-9
      互助单元: 福建医科大学隶属泉州第一医院、上海宝藤生物、银河生物
      ######
    • 62. Y. Chen, Y. Li, C. Qi, C. Zhang, D. Liu, Y. Deng, Y. Fu, V.S. Khadka, D.D. Wang, S. Tan, S. Liu, Z. Peng, J. Gong, P.P. Lin, X. Zhang, J. Li, Y. Li, L. Shen (2021) Dysregulated KRAS gene-signaling axis and abnormal chromatin remodeling drive therapeutic resistance in heterogeneous-sized circulating tumor cells in gastric cancer patients. Cancer Lett 517:78-87

      要害词:iFISH CTC单细胞测序、大/小细胞 CTC、改进型MDA全基因组扩增、银河固/液双相单细胞显微分散、预后、耐药、胃癌
      互助单元:北京大学肿瘤中心、北京肿瘤医院、美国夏威夷大学医学院、泰州健为医学、银河生物
      ######
    • 62R1. D. Loreth, M. Schuette, J. Zinke, M. Mohme, A. Piffko, S. Schneegans, et al. (2021) CD74 and CD44 Expression on CTCs in Cancer Patients with Brain Metastasis. Intl J Mol Sci 22:6993

      要害词:肺癌/乳腺癌/恶性玄色素瘤脑转移展望、CD44+/CD74+ 双阳CTC
      互助单元:德国汉堡大学医学中心、德国癌症研讨中心等
      ######
    • 62R2. A. Liu et al. (2021) Silencing ZIC2 abrogates tumorigenesis and anoikis resistance of non-small cell lung cancer cells by inhibiting Src/FAK signaling. Mol Ther Oncolytics 22:195

      要害词:锌指卵白、非小细胞肺癌、CTC、SE-iFISH
      互助单元:中南大学湘雅医院、国度遗传病临床研讨中心、中山大学江门中心医院、广东医科大学、银河生物
      ######
    • 61. P.P. Lin (2021) Chapter: Liquid Biopsy Analysis of Circulating Tumor Biomarkers in Lung Cancer, in the book “Lung Cancer – Modern Multidisciplinary Management” edited by Henry S. Park, Yale University School of Medicine; published by IntechOpen Publisher, London, UK.

      要害词:肺癌液体活检、CTC及CTEC、CTC-derived xenograft (CDX)
      互助单元:银河生物
      ######
    • 61R1. C. Xing, Y. Li, C. Ding, S. Wang, H. Zhang, L. Chen, P Li, M. Dai (2021) CD44+ Circulating Tumor Endothelial Cells Indicate Poor Prognosis in Pancreatic Ductal Adenocarcinoma After Radical Surgery: A Pilot Study. Cancer Manag Res 13:4417-4431

      要害词:胰腺癌、CD44+ CTEC及CTC、术后疾速复发、SE-iFISH
      互助单元:北京协和医院内科、银河生物
      ######
    • 60. H. Cheng, S. Wang, W. Luan, X. Ye, S, Dou, Z. Tang, H. Zhou, P.P. Lin, Y. Li, H. Cui, and X. Chang (2021) Combined detection and subclass characteristics analysis of CTCs and CTECs by SE-iFISH in ovarian cancer. Chin J Cancer Res 33:256-270

      要害词:卵巢癌诊断、CTC、SE-iFISH
      互助单元:北京大学人民医院妇产科、妇科肿瘤中心、银河生物
      ######
    • 60R. H. Cheng et al. (2021) Preliminary Safety and Potential Effect of 6B11-OCIK Adoptive Cell Therapy Against Platinum-Resistant Recurrent or Refractory Ovarian Cancer. Front Immunol 12:707468.

      要害词:卵巢癌、细胞免疫医治、CD31- CTC与CD31+ CTEC、SE-iFISH
      互助单元:北京大学人民医院妇产科、妇科肿瘤中心、银河生物
      ###
    • 59. Y.Hong, J. Si, J. Zhang, Y. Xiong, J. Zhang, P. Lin, J. Fang, Y. Yang, C. Lv and Y. Ma (2021) Small Cell Size Circulating Aneuploid Cells as a Biomarker of Prognosis in Resectable Non-Small Cell Lung Cancer. Front Oncol 11:590952

      要害词:晚期肺癌、术前CTC、小细胞三倍体CTC、预后
      互助单元:北京大学肿瘤中心、北京肿瘤医院胸内科及胸外科、银河生物
      ######
    • 58.P. P. Lin (2020) Aneuploid Circulating Tumor-Derived Endothelial Cell (CTEC): A Novel Versatile Player in Tumor Neovascularization and Cancer Metastasis. Cells 9:1539

      要害词:CTEC、肿瘤细胞内皮化、肿瘤微情况、肿瘤新血管天生、肿瘤转移、hypoxia、EMT、EndoMT
      互助单元:银河生物
      ######
    • 58R. Y. Lei, N. Sun, G. Zhang, C. Liu, Z. Lu, J. Huang, C. Zhang, R. Zang, R. Che, S. Mao, L. Fang, X. Wang, S. Zheng, J. He (2020) Combined detection of aneuploid circulating tumor-derived endothelial cells and circulating tumor cells may improve diagnosis of early stage non-small-cell lung cancer. Clin Transl Med e128

      要害词:肺癌早筛、肺小结节、CTEC、CTC、银河SE-iFISH
      互助单元:中国国度癌症中心、中国国度临床肿瘤医学研讨中心、中国医学迷信院暨北京协和医学院肿瘤医院 – 赫捷院士、院长团队、银河生物
      ###
    • 57. Y. Chen, C. Qi, J. Yuan, D. Liu, Z. Peng, X. Zhang, J. Li, P.P. Lin, Y. Li, L. Shen (2020) Elevated PD-L1 and HER2 expression on aneuploid carcinoma cells in malignant ascites accelerates tumor cell immune evasion in gastrointestinal cancer patients. Cancer Res 80:5381a

      要害词:恶性腹水肿瘤细胞、PD-L1、 HER2、免疫逃逸、胃癌
      互助单元:北京大学肿瘤中心、北京肿瘤医院、银河生物
      ######
    • 56.  程洪艳,李一林,王书航,刘颖,王丹丹,林平,昌晓红 (2020) 使用SE-iFISH同步团结检测异倍体CTC与CTEC的紧张临床意义。《临床实行室》(Clinical Laboratory) 14(5):43-48

      要害词:瘤标、异倍体、循环肿瘤血管内皮细胞CTEC、SE-iFISH
      互助单元:北京大学人民医院妇科肿瘤中心、北京大学肿瘤中心、北京肿瘤医院、中国国度癌症中心、中国医学迷信院、北京协和医学院肿瘤医院 、银河生物
      ###
    • 55. L. Zhang, X. Zhang, Y. Liu, T. Zhang, Z. Wang, M. Gu, Y. Li, D.D. Wang, W. Li, P.P. Lin (2020) PD-L1+ aneuploid circulating tumor endothelial cells (CTECs) exhibit resistance to the checkpoint blockade immunotherapy in advanced NSCLC patients. Cancer Lett 469:355-366

      要害词:非小细胞肺癌、PD-L1+ CTC 及 CTEC、免疫医治耐药
      互助单元:都城医科大学隶属北京胸科医院、北京大学肿瘤中心、北京肿瘤医院、银河生物
      ######
    • 54. Y. Zhao, J. Li, D. Li, Z. Wang, J. Zhao, X. Wu, Q. Sun, P.P. Lin, P. Plum, A. Damanakis, F. Gebauer, M. Zhou, Z. Zhang, H. Schlosser, K-W Jauch, P.J. Nelson, C.J. Bruns (2020) Tumor biology and multidisciplinary strategies of oligometastasis in gastrointestinal cancers. Semin Cancer Biol 60:334-343

      要害词:肿瘤寡转移OMD、肿瘤微情况、CTC及CTEC
      互助单元:德国科隆大学、德国慕尼黑大学、上海复旦大学肿瘤中心、上海长海医院、银河生物
      ######
    • 54R. G. Ma, Y. Jiang, M. Liang, J. Li, J. Wang, X. Mao, J. S. Veeramootoo, T. Xia, X. Liu, S. Wang (2020) Dynamic monitoring of CD45-/CD31+/DAPI+ circulating endothelial cells aneuploid for chromosome 8 during neoadjuvant chemotherapy in locally advanced breast cancer. Ther Adv Med Oncol 12:1-14

      要害词:新帮助化疗、乳腺癌、CTEC、CTC、银河SE-iFISH
      互助单元:江苏省人民医院暨南京医科大学第一隶属医院乳腺内科、江苏省乳腺疾病诊疗中心、江苏省妇幼保健医院、银河生物
      ###
    • 53. X. Liu, J. Li, B. L. Cadilha, A. Markota, C. Voigt, Z. Huang, P. P. Lin, D. D. Wang, J. Dai, G. Kranz, A. Krandick, D. Libl, H. Zitzelsberger, I. Zagorski, H. Braselmann, M. Pan, S. Zhu,Y. Huang, S. Niedermeyer, C. A. Reichel, B. Uhl, D. Briukhovetska, J. Suárez, S. Kobold, O. Gires, and H. Wang (2019) Epithelial-type systemic breast carcinoma cells with a restricted mesenchymal transition are a major source of metastasis (SA Highlights). Science Advances 5, eaav4275

      要害词:乳腺癌转移、肿瘤植物模子、原代肿瘤细胞培育、EpCAM+ CTCs与DTCs、单细胞测序
      互助单元:上海交大隶属上海第一人民医院、德国慕尼黑大学、GSK制药、复旦大先生科院、南京医科大学、银河生物等
      ######
    • 52. Y. Wang, Y. Liu, L. Zhang, L. Tong, Y. Gao, F. Hu, P. P. Lin, B. Li, T. Zhang (2019) Vimentin expression in circulating tumor cells (CTCs) associated with liver metastases predicts poor progression-free survival in patients with advanced lung cancer. J Cancer Res Clin Oncol 145:2911-2920

      要害词:SCLC及NSCLC、肺癌定向肝转移、预后、间质化CTC
      互助单元:都城医科大学隶属北京胸科医院、银河生物
      ######
    • 52R1. Z. Ye, Y. Ding, Z. Chen, Z. Li, S. Ma, Z. Xu, L. Cheng, X. Wang, X. Zhang, N. Ding, Q. Zhang, and Q. Qian (2019) Detecting and phenotyping of aneuploid circulating tumor cells in patients with various malignancies. Cancer Biol Ther 20:546

      要害词:普筛多瘤种CTC、间质化小细胞CTC、SE-iFISH
      互助单元:上海白泽医学查验所、上海细胞医治团体研讨中心、二军医大隶属上海西方肝胆内科医院生物医治中心、美国印第安纳大学医学院病理与临床查验中心
      ###
    • 52R2. Y. Zhang, J. Li, Li. Wang, P. Meng, J. Zhao, P. Hang, J. Xia, J. Xu, Li. Wang, F. Shen, A. Zheng, F. Zhou and R. Fan (2019) Clinical significance of detecting circulating tumor cells in patients with esophageal squamous cell carcinoma by EpCAM-independent enrichment and immunostaining-fluorescence in situ hybridization. Mol Med Rep 20:1551

      要害词:食管癌、新帮助化疗、术后CTC静态监测、预后评价、SE-iFISH
      互助单元:郑大一附院、河南安阳市肿瘤医院、上海张江转化医学中心、上海宝藤医学查验所
      ###
    • 51. Y. Li, X. Zhang, D. Liu, J. Gong, D. Wang, S. Li, Z. Peng, Y. Li, X. Wang, P. Lin, M. Li, and L. Shen (2018) Evolutionary expression of HER2 conferred by chromosome aneuploidy on circulating gastric cancer cells contributes to developing targeted and chemotherapeutic resistance (CCR Highlights). Clin Cancer Res 24:5261-71

      要害词:胃癌、CTC HER2与构造 HER2、CTC与耐药及不良预后
      互助单元:北京大学肿瘤中心、北京肿瘤医院、美国奥克拉荷马大学医学中心、银河生物
      ######
    • 50. P. Lin, J. Li, D. Wang, O. Gires, H. Wang (2018) EpCAM differentially expressed on circulating and disseminated tumor cells promotes tumor metastasis in breast cancer patients. Cancer Res 78:1059a

      要害词:乳腺癌转移、EpCAM+ CTCs和DTCs、疗效和预后
      互助单元:上海交大隶属上海第一人民医院、德国慕尼黑大学、银河生物等
      ###
    • 49. J. Zhang, H. Shi, T. Jiang, Z. Liu, P.P. Lin, and N. Chen (2018) Circulating tumor cells with karyotyping as a novel biomarker for diagnosis and treatment of nasopharyngeal carcinoma. BMC Cancer 18:1133

      要害词:鼻咽癌、CTC检测、肿瘤分期、化疗疗效、耐药
      互助单元:华中医院肿瘤中心、肿瘤放疗科及生物医治国度重点实行室、银河生物
      ######
    • 48. P. Lin (2018) Aneuploid CTC and CEC. Diagnostics 8(2):26(1-13)

      要害词:CTC与CTEC、染色体非常、SE-i•FISH、单细胞测序
      互助单元:银河生物
      ######
    • 47. L. Wang, Y. Li, J. Xu, A. Zhang, X. Wang, R. Tang, X. Zhang, H. Yin, M. Liu, D. Wang, P. Lin, L. Shen, J. Dong (2018) Quantified postsurgical small cell size CTCs and EpCAM+ circulating tumor stem cells with cytogenetic abnormalities in hepatocellular carcinoma patients determine cancer relapse. Cancer Lett 412:99-107

      要害词:肝癌、术后复发、小细胞CTC、EpCAM+ CTC、CTM
      互助单元:清华大学隶属北京清华长庚医院 – 董家鸿院士、院长团队、北京大学肿瘤中心、北京肿瘤医院、束缚军301总医院、银河生物
      ######
    • 47R1. X. Liu, Z. Zhang, B. Zhang, Y. Zheng, C. Zheng, B. Liu, S. Zheng, K. Dong, R. Dong (2018) Circulating tumor cells detection in neuroblastoma patients by EpCAM-independent enrichment and immunostaining-fluorescence in situ hybridization. EBioMedicine 35:244

      要害词:神经母细胞瘤、预后评价、转移诊断、SE-iFISH
      互助单元:复旦大学隶属儿科医院、上海张江转化医学中心、上海宝藤医学查验所
      ###
    • 47R2. Z. Su, J. Zhao, S. KE, J. Zhang, X. Liu, Y. Wang, Q. Sun and Q. Pan (2018) Clinical significance of circulating tumor cells via combined whole exome sequencing in early stage cancer screening: A case report. Exp Ther Med 16:2527

      要害词:肿瘤早筛、结直肠癌、结肠息肉、单细胞CTC全外显子测序、SE-iFISH
      互助单元:福建泉州第一医院、上海张江转化医学中心、上海宝藤医学查验所
      ###
    • 46. X. Li, Y. Zhang, J. Ding, M. Wang, N. Li, H. Yang, K. Wang, D. Wang, P. Lin, M. Li, Z. Zhao, and P. Liu (2017) Clinical significance of detecting CSF-derived tumor cells in breast cancer patients with leptomeningeal metastasis. Oncotarget 9:2705-14

      要害词:乳腺癌脑转移、原代肿瘤细胞培育、NGS、引导个别化筛药
      互助单元:大连医科大学肿瘤干细胞研讨所、大连医大第二隶属医院、银河生物
      ######
    • 45. P. Lin, O. Gires, D. Wang, L. Li and H. Wang (2017) Comprehensive in situ co-detection of aneuploid circulating endothelial and tumor cells. Sci Rep 7:9789

      要害词:CD31、异倍体循环血管内皮细胞CTEC、肿瘤血管天生、CTC活性
      互助单元:上海市第一人民医院肿瘤中心、德国慕尼黑大学、银河生物
      ######
    • 45R. Y. Xu, T. Qin, J. Li, X. Wang, C. Gao, C. Xu, J. Hao, J. Liu, S. Gao and H. Ren (2017) Detection of Circulating Tumor Cells Using Negative Enrichment Immunofluorescence and an In Situ Hybridization System in Pancreatic Cancer. Int J Mol Sci 18:622

      要害词:胰腺癌CTC、癌栓CTM、三倍体,CA19-9,化疗敏感与耐药、预后、SE-iFISH
      互助单元:中国国度临床肿瘤医学研讨中心肿瘤防治重点实行室、天津医科大学肿瘤医院暨肿瘤研讨所
      ###
    • 44. 由磊,赵烨,阚秀,李一林,王东民,张爱群,王彤霞,刘颖,王丹丹,林平,郑直 (2017) 同步原位检测 CTC 多重瘤标卵白表达与染色体异倍体的意义及使用。《临床与实行病理学杂志》 (J Clin Exp Pathol) 33:297-302

      要害词:液体活检、CTC、临床意义
      互助单元:北京协和医院、中国医学迷信院底子医学研讨所、北京肿瘤医院、束缚军301医院、北京大学第一医院、银河生物
      ######
    • 44R. W. Wu, Z. Zhang, X. Gao, Z. Shen, Y. Jing, H. Lu, H. Li, X. Yang, X. Cui, Y. Li, Z. Lou, P. Liu, C. Zhang, W. Zhang (2017) Clinical significance of detecting circulating tumor cells in colorectal cancer using subtraction enrichment and immunostaining-fluorescence in situ hybridization (SE-iFISH) Oncotarget 8:21639

      要害词:结直肠癌、术前与术后CTC、术后复发及预后、SE-iFISH
      互助单元:西安交大隶属陕西汉中3201医院普内科、上海张江转化医学中心、二军医大隶属长海医院结直肠癌内科
      ###
    • 43. Y. Li, X. Zhang, D. Liu, J. Gong, D.D. Wang, P.P. Lin, and L. Shen (2017) Dynamic acquisition of HER2 expression on circulating tumor cells in gastric cancer patients correlates to developing therapeutic resistance. Cancer Res 77:3795a

      要害词:胃癌、HER2+ CTC、耐药
      互助单元:北京大学肿瘤中心、北京肿瘤医院、美国奥克拉荷马大学医学中心、银河生物
      ###
    • 43R. Y. Sheng, T. Wang, H. Li, Z. Zhang, J. Chen, C. He, Y. Li, Y. Lv, J. Zhang, C. Xu, Z. Wang, C. Huang and L. Wang (2017) Comparison of analytic performances of Cellsearch and iFISH approach in detecting circulating tumor cells. Oncotarget 8:8801

      要害词:乳腺癌、CellSearch 阳性率 38%、SE-iFISH 阳性率 91%
      互助单元:第二军医大学隶属上海长海医院、第四军医大学隶属西安西京医院、上海张江转化医学中心、上海宝藤医学查验所
      ###
    • 42. H. Wang, N. Stoecklein, P. Lin and O. Gires (2017) Circulating and disseminated tumor cells: diagnostic tools and therapeutic targets in motion (Review). Oncotarget 8:1884-1912

      要害词:CTC与DTC检测、医治靶标
      互助单元:上海交通大学隶属上海市第一人民医院肿瘤中心、德国慕尼黑大学、银河生物
      ######
    • 41. Y. Li, X. Zhang, J. Gong, Q. Zhang, J. Gao, Y. Cao, D. D. Wang, P.P. Lin, and L. Shen (2016) Aneuploidy of chromosome 8 in circulating tumor cells correlates with prognosis in patients with advanced gastric cancer. Chin J Cancer Res 28:579-588

      要害词:早期胃癌、8号染色体异倍体、CTC、预后
      互助单元:北京大学肿瘤中心、北京肿瘤医院、银河生物
      ###
    • 41R. Y. Gao, Y. Zhu, Z. Zhang, C. Zhang, X. Huang and Z. Yuan (2016) Clinical significance of pancreatic circulating tumor cells using combined negative enrichment and immunostaining-fluorescence in situ hybridization. J Exp Clin Cancer Res 35:66

      要害词:胰腺癌、部分与转移、预后、SE-iFISH
      互助单元:上海交通大学隶属上海市第六人民医院、上海张江转化医学中心、上海宝藤医学查验所
      ###
    • 40. P. Lin (2016) NGS analysis of the single CTC or DTC isolated and subtyped by the integrated subtraction enrichment and immunostaining-FISH. Cancer Res 76:489a

      要害词:EMT、差相富集 、CTC亚类
      互助单元:银河生物
      ###
    • 40R. F. Gao, Y. Cui, H. Jiang, D. Sui, Y. Wang, Z. Jiang, J. Zhao, S. Lin (2016) Circulating tumor cell is a common property of brain glioma and promotes the monitoring system. Oncotarget 7:71330-71340

      要害词:胶质瘤、CTC、疗效评价、银河SE-iFISH
      互助单元:都城医科大学隶属北京天坛医院、中国国度神经体系疾病临床医学研讨中心、北京脑严重疾病研讨院、北京脑肿瘤研讨重点实行室、北京清华大学第一隶属医院
      ###
    • 39. P. Lin (2015) Integrated EpCAM-independent subtraction enrichment and iFISH strategies to detect and classify disseminated and circulating tumors cells. Clin Transl Med 4(38):1-7

      要害词:SE-iFISH、CTC分类、临床意义
      互助单元:银河生物
      ######
    • 38. F. Ge, H. Zhang, D. Wang, L. Li and P. Lin (2015) Enhanced detection and comprehensive in situ phenotypic characterization of circulating and disseminated heteroploid epithelial and glioma tumor cells. Oncotarget 6 (29): 27049-27064

      要害词:CTC 和 DTC 亚型、差相富集 (SE)、原位表型和核型剖析 (iFISH)
      互助单元:北京向阳医院、复旦大学西岳医院、银河生物
      ######
    • 37. P. Lin, L. Li, and D. Wang (2015) A novel integrated iFISH technology to detect and characterize non-hematopoietic heteroploid CTC subtypes with or without expressing vimentin or other tumor biomarkers. Cancer Res 75:557

      要害词:iFISH 技能、检测并分型 CTC
      互助单元:银河生物
      ###
    • 36. J. Jiang, D. Wang,  M. Yang, D. Chen, L. Pang, S. Guo, J. Cai, J.P. Wery, L. Li, H. Li,and P. Lin (2015) Comprehensive characterization of chemotherapeutic efficacy on metastases in the established gastric neuroendocrine cancer patient derived xenograft model. Oncotarget 6(17):15639-15651

      要害词:CTC 亚型、转移性 PDX、耐药、表型和核型剖析 (iFISH)
      互助单元:北京大学自然药物与仿生药物国度重点实行室、中美冠科生物技能有限公司、银河生物
      ######
    • 35. Y.Li, X. Zhang, S. Ge, J. Gao, J. Gong, M. Lu, Q. Zhang, Y. Cao, D. Wang, P. Lin, L. Shen (2014) Clinical Significance of Phenotyping and Karyotyping of Circulating Tumor Cells in Patients with Advanced Gastric Cancer. Oncotarget>###2

      要害词:胃癌、CTC、核型剖析、耐药监测
      互助单元:北京大学肿瘤中心、北京肿瘤医院、银河生物
      ###
    • 34. R. Ran, L. Li, M. Wang, S. Wang, Z. Zheng, and P. Lin (2013) Determination of EGFR mutation in single cells microdissected from enriched lung tumor cells in peripheral blood. Anal. Bioanal. Chem. 405(23):7377-7382

      要害词:肺癌、CTC、单细胞测序、EGFR 渐变
      互助单元:北京协和医院、中国医学迷信院底子医学研讨所、银河生物
      ###
    • 33. J. Jiang, D.D. Wang, M. Yang, D. Chen, S. Guo, J. Cai, L. Li, J-P. Wery, P. Lin, and H. Li (2013) Metastatic PDX modeling displays correlation between CTC and metastatic potential, both inhibited by chemotherapy. Mol. Cancer Ther. 12:157

      要害词:PDX 模子、CTC 、转移潜能
      互助单元:中美冠科生物技能有限公司、银河生物
      ###
    • 32. Q. Chen, F. Ge, W. Cui, F. Wang, Z. Yang, Y. Guo, L. Li, R. Bremner, and P. Lin (2013) Lung Cancer Circulating Tumor Cells Isolated by the EpCAM-Independent Enrichment Strategy Correlate with Cytokeratin 19-Derived CYFRA21-1 and Pathological Staging. Clin. Chim. Acta 419:57-61

      要害词:肺癌、CTC、病理分期、CYFRA21-1
      互助单元:北京协和医院、世纪坛医院、圣约瑟夫医院、银河生物
      ###
    • 31. X. Zhou, L. Li, H. Hao, S. Wang, Z. Guo, M. Wang, L. Zhang, W. Zhong, R. Ran, X. Zhang, L. Xu, and P. Lin (2010) Circulating tumor cells as a prognostic and predictive indicator in advanced lung cancer patients. Oncol. Progress 8(5):484-490

      要害词:肺癌、CTC、疗效
      互助单元:北京协和医院、都城医科大学隶属北京胸科医院、银河生物
      ###
    • 30. C. Wu, H. Hao, L. Li, X. Zhou, Z. Guo, L. Zhang, X. Zhang, W. Zhong, H. Guo, R. Bremner, and P. Lin (2009) Preliminary investigation of the clinical significance of detecting circulating tumor cells enriched from lung cancer patients. J. Thorac. Oncol. 4:30-36

      要害词:循环肿瘤细胞 (CTC) 、肺癌、CT、化疗疗效评价、复发
      互助单元:北京协和医院、北京微生物与盛行病研讨所、银河生物
      ###
    • 29. P. Lin, C. Lavoie, T. Fischer, H. Huang, and M. Farquhar (2009) Calnuc plays a role in dynamic distribution of Galphai but not Gbeta subunits and modulates ACTH secretion in AtT-20 neuroendocrine secretory cells. 
      Mol. Neurodegener. 4:1-16

      要害词:G-卵白、调治性细胞外泌
      ###
    • 28. L. Li, X. Zhou, H. Hao, M. Wang, Z. Guo, S. Wang, X. Xing, G. Harvie, E. Vuong, W. Shi, M. Tang, J. Rao, T. Reid, R. Bremner, P. Lin, J. Xu (2008) Detection of circulating tumor cells in newly diagnosed or relapsed lung cancer patients and the significance of CTC enumeration in patient staging. Cancer Res. 68:3691

      要害词:非小细胞肺癌、CTC 计数、临床分期、影像学
      互助单元:加州大学洛杉矶分校、加州大学圣地亚哥分校、圣约瑟夫医院、银河生物
      ###
    • 27. D. Wang, Y, Liu, Y. Liu, C. Wang, H. Bao, H. Hao, S. Wang, Y. Zhang, H. Yu, X. Xing, G. Harvie, E. Vuong, J. Rao, T. Reid, P. Lin, J. Xu (2008) Enrichment and detection of circulating tumor cells in breast cancer patients. Cancer Res. 68:3692

      要害词:乳腺癌、分期与疗效、CTC 计数
      互助单元:北京大学第一医院、加州大学圣地亚哥分校、银河生物
      ###
    • 26. H. Guo, H. Hao, Z. Li, Y. Zhu, J. Sun, F. Ge, S. Wang, X. Xing, G. Harvie, E. Vuong, J. Rao, R. Bremner, T. Reid, P. Lin, J. Xu (2008) Preliminary investigation of lung cancer CTC distribution in patient body circulation. Cancer Res. 68:3694

      要害词:肺静脉、桡动脉和外周血 CTC 、明显性差别
      互助单元:北京协和医院、加州大学圣地亚哥分校、银河生物
      ###
    • 25. Y, Chen, H. Bao, C. Zhou, X. Xing, G. Harvie, E. Vuong, J. Rao, T. Reid, H. Qiu, Y. Xiao, H. Wu, M. Mei, C. Lu, P. Lin and J. Xu (2008) Detection of circulating tumor cell in patients with colorectal cancer and its potential implication. Cancer Res. 68:3696

      要害词:结直肠癌、CTC、肿瘤侵袭性
      互助单元:北京协和医院、加州大学圣地亚哥分校、加州大学洛杉矶分校、银河生物
      ###
    • 24. X. Zhou, L. Li, M. Wang, L. Zhang, P. Lin and J. Xu (2008) Circulating tumor cells (CTC) as a prognostic and predictive factor in lung cancer patients. J Clin Oncol 26(15):22201

      要害词:肺癌、CTC、预后
      互助单元:北京协和医院、银河生物
      ###
    • 23. C. Ren, P. He, J. Zhang, Z. Zheng, Y. Xu, L. Zhou, H. Qiao, C. Wang, P. Zhao, W. Shi, M. Tang, P. Lin, and J. Xu (2007) Detecting circulating tumor cells in peripheral blood of pancreatic cancer patients using negative selection strategy. Cancer Res. 67:5445

      要害词:差相富集、CTC、胰腺癌
      互助单元:中国国度癌症中心、中国国度临床肿瘤医学研讨中心、中国医学迷信院肿瘤医院、银河生物
      ###
    • 22. W. Shi, T. Reid, M. Tang, G. Harvie, H. Tao, G. Tao, P. Lin, and J. Xu (2007) Detection of circulating cancer cells from lung cancer patient blood samples and correlation with anti-cancer therapy. Cancer Res. 67:5444

      要害词:肺癌、CTC、化疗
      互助单元:北京协和医院、加州大学圣地亚哥分校、银河生物
      ###
    • 21. H. Yu, P. Lin, Y. Xu, Y. Zhou, Q. Sun, and J. Xu (2007) Breast cancer and circulating tumor cells (Review). Chn. J. Med. Lab. Tech. 8(3):215-218

      要害词:乳腺癌、循环肿瘤细胞
      互助单元:北京协和医院、银河生物
      ###
    • 20. Y. Chen, P. Lin, S. Qiu, XX. Peng, K. Loi, MG Farquhar and JY. Zhang (2007) Autoantibodies to Ca2+ binding protein Calnuc is a potential marker in colon cancer detection. Int. J. Oncol. 30(5):1137-44

      ###
    • 19. P. Lin, F. Li, Y. Zhang, H. Huang, G. Tong, M. Farquhar and H. Xu (2007) Calnuc binds to Alzheimer’s beta-amyloid precursor protein and affects its biogenesis. J. Neurochem. 100:1505-1514

      ###
    • 18. Y. Chen, P. Lin, K. Looi, R. Megliorino, and J. Zhang (2005) Autoantibodies to calcium binding protein Calnuc might be a potential marker in colon cancer detection. Cancer Res. 65:561

      ###
    • 17. P. Lin, C. Ren, X. Zhao, L. Li, Y. Qiao , G. Harve, H. Tao, E. Vuong, G. Tao, M, Huang, L. Wu, and J. Xu (2005) Role of detecting circulating tumor cell in clinical cancer diagnosis and therapy. Chn. J. Lab. Tech. 1 (1):1-6

      要害词:循环肿瘤细胞检测、临床肿瘤诊断和医治
      互助单元:中国国度癌症中心、中国国度临床肿瘤医学研讨中心、中国医学迷信院肿瘤医院、北京协和医院、银河生物
      ###
    • 16. Y-W. Zhang, W-J Luo, H. Wang, P. Lin, K.S. Vetrivel, F. Liao, F. Li, P.C. Wong, M.G. Farquhar, G. Thinakaran, and H. Xu (2005) Nicastrin is critical for stability and trafficking but not association of other presenilin/γ-secretases components. J. Biol. Chem. 280:17020-17026

      ###
    • 15. C. Lavoie, T. Meerloo, P. Lin , and M.G. Farquhar (2002) Calnuc, an EF-Hand Ca2+-binding protein, is stored and processed in the Golgi and secreted by the constitutive-like pathway in AtT-20 cells. Mol. Endocrinol. 16:2462-2474

      ###
    • 14. T.S.Weiss, C.E. Chamberlain, T. Takeda, P. Lin, K.M. Hahn, and M.G. Farquhar (2001) Galphai3 binding to calnuc on Golgi membranes in living cells monitored by fluorescence resonance energy transfer (FRET) of green fluorescent protein fusion proteins. Proc. Natl. Acad. Sci. USA. 98:14961-14966

      ###
    • 13. P. Lin, T. Fischer, T. Weiss, and M.G. Farquhar (2000) Calnuc, an EF-hand Ca2+ binding protein, specifically interacts with the C-terminal alpha5-helix region of Galphai3. Proc. Natl. Acad. Sci. USA. 97:674-679

      ###
    • 12. P. Lin, C. Lavoie, T. Fischer and M.G. Farquhar (2000) Calnuc regulates ACTH secretion in AtT-20 cells. Mol. Biol. Cell 11:50

    • 11. P. Lin, Y. Yao, R. Hofmeister, R.Y. Tsien and M.G. Farquhar (1999) Overexpression of CALNUC (nucleobindin) increases agonist and thapsigargin relesable Ca2+ storage in the Golgi. J. Cell Biol. 145:279-289

      ###
    • 10. P. Lin, T. Fischer, T. Weiss, and M.G. Farquhar (1999) Calnuc, an EF-hand Ca2+ binding protein, specifically interacts with the C-terminal region of Galphai3. Mol. Biol. Cell 10:418

      ###
    • 9.P. Lin, H. Le-Niculescu, R. Hofmeister, J.M. McCaffery, M. Jin, H. Hennemann, T. McQuistan, L. De Vries, and M.G. Farquhar (1998) The mammalian Ca2+ binding protein, nucleobindin (CALNUC), is a Golgi resident protein. J. Cell Biol. 141:1515-1527

      ###
    • 8.P. Lin, Y. Yao, R. Hofmeister, R.Y. Tsien and M.G. Farquhar (1998) Overexpression of CALNUC increases agonist and thapsigargin relesable Ca2+ storage in the Golgi. Mol. Biol. Cell 9:99

      ###
    • 7. H. Le-Niculescu, P. Lin, M. Jin, H. Hennemann, D. Heinegard, T. McQuistan, J. M. McCaffery, N. Watson, L. De Vries, and M.G. Farquhar (1997) Characterization of a Golgi-associated EF-hand/ Ca2+ binding protein that interacts with heterotrimeric Galphai protein subunits. Mol. Biol. Cell 8:338

    • 6. Y-P. Li, G. Curley, M. Lopez, M Chavez, R. Glew, A. Aragon, H. Kumar, and O.G. Baca (1996) Protein-tyrosine phosphatase activity of Coxiella Burnetii that inhibits human neutrophils. Acta Virologica 40:263-272

    • 5. P. Lin, C. Mold, and T.W. DuClos (1995) Characterization of the C-reactive protein (CRP) receptor on the human monocytic cell line THP-1 (704). Immunol. Today 16(7):305-62

    • 4. O.G. Baca, Y-P. Li, and H. Kumar  (1994) Survival of the Q fever agent Coxiella Burnetii in the phagolysosome. Trends in Microbiol. 2(12):476-480

    • 3. Y-P. Li, C. Mold, and T.W. DuClos (1994) Sublytic Complement Attack Exposes C-Reactive Protein Biding Sites on Cell Membranes. J. Immunol. 152:2995-3005

    • 2. T. Nakagaki, P. Lin, and W. Kisiel (1992) Activation of human factor VII by the prothrombin activator from the venom of Oxyuranus Scutellatus(taipan snake). Thrombosis Res. 65:105-116

    • 1. P. Lin, Q.S. Lin, and S.Q. Nie (1992) Primary study of application of liposome immunolysis assay on drug monitoring. Prog. Clin. Biochem.p515-516. Editors: K. Miyai, T. Kanno, and E. Ishikawa. Excerpta Medica Publishing.

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